Direct message the job poster from SciPro Job Title: Principal Scientist / Director, Medicinal Chemistry (Small Molecules) Location: Cambridge, MA Employment Type: Full-Time About the Role: A commercially successful, innovation-driven pharmaceutical company based in Cambridge, MA is seeking an accomplished Principal Scientist or Director in Medicinal Chemistry to join their growing small molecule drug discovery team. This is a high-impact role offering the opportunity to lead early- and late-stage discovery programs with direct visibility to senior leadership. The ideal candidate will bring deep synthetic and medicinal chemistry expertise, strategic leadership, and a successful track record of drug discovery in large pharma environments. Key Responsibilities: Lead cross-functional medicinal chemistry efforts from hit generation through candidate nomination and into preclinical development. Design and execute synthetic strategies to optimize potency, selectivity, PK, and safety of small molecule drug candidates. Partner closely with DMPK, biology, structural biology, and computational chemistry to guide SAR and compound profiling. Mentor and manage internal scientists and external CRO resources. Contribute to portfolio strategy and shape the future of the small molecule pipeline. Communicate data and strategy effectively to stakeholders across discovery, development, and executive leadership. Qualifications: Ph.D. in Organic or Medicinal Chemistry with 10+ years of industry experience in small molecule drug discovery. Proven success advancing programs to development candidate stage, ideally through IND-enabling studies. Current or recent experience in large pharma is required Deep understanding of structure-based drug design, SAR development, and synthetic optimization. Demonstrated leadership and project ownership in multidisciplinary team settings. Strong communication, strategic thinking, and mentoring capabilities. Seniority level Seniority level Director Employment type Employment type Full-time Job function Job function Research Industries Pharmaceutical Manufacturing and Biotechnology Research Referrals increase your chances of interviewing at SciPro by 2x Get notified about new Director of Chemistry jobs in Boston, MA . Head of Analytical Development & Quality Control Andover, MA $216,000.00-$270,000.00 3 days ago Director of Chemistry / Chemist Principal Scientist Director, Global Compound Management (GCM) Director, Small Molecule Chemical Development Associate Director / Director, Quality Control Senior Manager/Associate Director, CMC Quality Assurance Senior Director, Analytical Development/Quality Control Director, Drug Substance (small molecules) Bedford, MA $216,000.00-$324,000.00 1 week ago Associate Director, Medicinal Chemistry - Helicon Degrader Design Sr. Manager/ Associate Director, NAP Kit Development Associate Director, External Manufacturing Associate Director, Analytical Development (Small Molecule) 2035840 Research (Scientific) Associate Director, Computational Chemistry Boston, MA $153,600.00-$241,340.00 1 day ago Director, Cardiometabolic Diseases, Inflammation, and Obesity - Translational Biology Executive Director, Oncology Discovery Chemistry, Oncology Targeted Discovery Director / Senior Director, Pharmacology Director, Global Compound Management (GCM) Associate Director CMC, Drug Product 2064423 We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI. #J-18808-Ljbffr SciPro
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